Symposia

Note that some of the presentation titles are yet to be announced

Affil'n Symposium Chair Speakers

ASB Fundamentals of Biophysics - development of mathematical and computational methods John Gehman

Philip Kuchel; University of Sydney and Singapore Bioimaging Consortium. Erythrocyte shape, metabolism and membrane transport - computations.
Mehdi Mobli; University of Queensland, Institute of Molecular Bioscience. Fast acquisition of multidimensional NMR experiments by maximum entropy reconstruction of non-uniformly sampled data.
David Szekely; Victor Chang Cardiac Research Institute. Toward the virtual heart: GPU accelerated interactive simulations of cardiac function.
Adelle Coster; University of New South Wales. Vesicle docking and Delivery: Life in the TIRF zone.

ASB Computational Studies on Biological and Synthetic Nanotubes Shin-Ho Chung

Alan Mark, University of Queensland. The induction and stabilization oftransmembrane pores by peptides.
Serdar Kuyucak, University of Sydney. Free energy simulations of Asp/Glu transporter GltPh.
Ben Corry, University of Western Australia. Monitoring the conformational changes involved in MscL channel gating using FRET microscopy and simulation.
Tamsyn Hilder, Australian National University. Mimicking biological ion channels using nanotubes.
International speaker:
Toby Allen, University of California Davis. Selective ion binding and its role in potassium channel selectivity.

Joint ASB/AuPS Mechanisms of multidrug resistance - the role of transporters in human disease Megan O'Mara
& Chris McDevitt

Melissa Brown, Flinders University. Bacterial multidrug resistance pumps
Rowena Martin, Australian National University. Multidrug resistance in the malarial parasite.
Tony George, University of Technology Sydney. Perspectives on multi-drug resistance.
International speakers:
Richard Callaghan, Oxford University (also presenting as an ASB Plenary speaker). ABCB1, ABCG2 multidrug resistance structure-function relationships.
Susan PC Cole, Queen’s University, Canada. Molecular mechanisms of drug sensitivity and resistance.

Joint ASB/AuPS Skeletal muscle: the coupling of excitation to contraction Nicole Beard

Brad Launikonis, University of Queensland. Voltage-dependent and -independent Ca²⁺ entry into skeletal muscle during excitation-contraction coupling.
Travis Dutka, La Trobe University, Coupling and uncoupling of the voltage-sensors and Ca²⁺ release channels in skeletal fibres. International speaker:
Robert Dirksen, University of Rochester Medical Center, NY (Also presenting as an ASB Plenary speaker). One is Enough: RyR1 Allele-Specific Gene Silencing in Mouse Models of MH and CCD

Joint ASB/AuPS Imaging and dynamic microscopy (imaging of biological and biophysical processes) Pierre Moens

Leann Tilley, La Trobe University, Imaging malaria parasite-infected erythrocytes using new high resolution modalities.
Alpha Yap, Inst for Molecular Bioscience, University of Queensland, Cadherin dynamics and the cytoskeleton.
Elizabeth Hinde, University of California, Irvine, In vivo pair correlation analysis of enhanced green fluorescent protein (EGFP) intra nuclear diffusion.
International speakers:
Enrico Gratton, University of California, Irvine. Detecting stem cell differentiation using fluorescence lifetime microscopy (FLIM) by the phasor approach.
Michelle Digman, Optical Biology Core Facility, UCI. Molecular transport in cells by the pair correlation fluctuation method.

Joint ASB/AuPS Calcium Signalling Grigori Rychkov
& Greg Barritt International speakers:

Richard Lewis, Stanford University, California. Title TBA
Oleg Gerasimenko, School of Biosciences, Cardiff University, UK. Calcium regulation of apoptosis in pancreatic acinar cells.
Andrew L. Miller, Hong Kong University of Science and Technology. The application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca²⁺ signaling during in vivo differentiation of slow muscle cells in zebrafish embryos.

Joint ASB/AuPS Lipid Metabolism and disease: new insights from the lab to the clinic Matthew Watt

Matthew Watt, Monash University. Circulating ceramides, inflammation and insulin resistance.
Graeme Lancaster, Baker IDI. Dual but opposing roles for dsRNA-dependent protein kinase (PKR) in obesity and inflammation.
Bronwyn Kingwell, Baker IDI. High density lipoproteins, diabetes and vascular function.
Leonie Heilbronn, University of Adelaide. Calorie restriction vs. exercise: the fitness vs. fatness debate rages.

Joint ASB/AuPS Ion channel modulation by peptide toxins Ray Norton
& David Adams

Glenn King, University of Queensland. Probing the interaction between psalmotoxin 1 and acid sensing ion channel 1a, an analgesic drug target.
Mary Chebib, University of Sydney. Calcium, Vc1.1 and α9α10 nicotinic acetylcholine receptors
David Adams, RMIT University. Analgesic conotoxins: modulation of voltage-gated calcium channels in pain pathways
Ray Norton, Monash University. Conotoxins targeting voltage-gated sodium channels: Designing new analgesics
International speaker:
Bob French, University of Calgary Canada. Subverting the biological actions of Conus peptides to modulate physiological responses.

Joint ASB/AuPS Molecular Physiology and Membrane Dynamics Jens Coorssen
& Peter Thorn

Frances Separovic, University of Melbourne. Membrane protein structure and function.
Boris Martinac, Victor Chang Cardiac Research Institute mechanisms of mechanosensation.
Ian Gibbins, Flinders University. Molecules in motion: imaging peptides, their receptors and diffusion models.
Brett Garner, University of Wollongong. Targeting membrane lipids to modulate amyloid precursor protein processing.
International speaker:
Paul Dietl, University of Ulm, Germany. Molecular control of surfactant secretion in type 2 alveolar cells.

AuPS Physiology Education Simon Potocnik & Ann Sefton

keynote speaker TBA- Inaugural AuPS, Excellence in Physiology Education, Michael Roberts medallist.
Yvonne M. Hodgson and J. Choate, Department of Physiology, Monash University. Using the Finapres to teach cardiovascular physiology to second year science students.
Richard Guy, RMIT University. The KISS approach. How to develop an effective self directed e-learning application.
David Saint, University of Adelaide. Lecture Attendance, Learning Style and Assessment Outcome in Physiology Students
Steven Wiederman, University of Adelaide. The Human Physiology Writing Centre: Mentors helping students with their writing tasks

AuPS Regulation of metabolic balance through co-ordination of central and peripheral signalling Chen Chen

Michael Cowley, Monash University. Control of energy balance by nutrient sensing neurons.
Frederik Steyn, University of Queensland. The importance of peripheral signals in regulating central control of GH secretion.
International speaker:
Jacque Epelbaum, INSERM-Molecular Neuroendocrinology Unit,  Paris France. Regulation of hypothalamic GHRH neuronal action by metabolic regulatory neurotransmitters

AuPS New insights into the molecular architecture of the heart and their implications for heart disease Yue-kun Ju & David Allen

Diane Fatkin, University of New South Wales. Mechanisms of contractile dysfunction in lamin A/C-deficient hearts.
Angela Dulhunty, John Curtin School of Medical Research ANU. Proteins in the lumen of the SR determine cardiac RyR channel activity and structure of Ca²⁺ release units.
Yue-kun Ju, University of Sydney. Distribution and functional role of IP3R receptors in mouse sino-atrial node.
International speakers:
Mark Boyett, University of Manchester, UK. The molecular architecture of the heart’s conduction system in health and disease.
Mark Cannell, University of Auckland, NZ. A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes.

AuPS Emerging Leaders in Developmental Physiology Caroline McMillen
& Helena Parkington

Karen Moritz, University of Queensland. Kidney development and regulation of blood pressure.
Tim Moss, Monash University. Inflammation and lung development.
Janna Morrison, University of South Australia. Early origins of cardiovascular disease: The heart of the matter.
James Armitage, Monash University. Developmental origins of obesity related hypertension.
Marianne Tare, Monash University. Early life environments and programming of the vascular phenotype

AuPS Stress, disease and Ca²⁺ management: the cardiovascular challenge. Lea M D Delbridge
& David Saint

Derek Laver, University of Newcastle. Cardiac SR Ca²⁺ release channels and adrenergic stimulation.
James R Bell, University of Melbourne. Cardiac ischemic stress: Ca²⁺ and sex scenarios.
Marie L Ward, University of Auckland, NZ. Cardiomyopathies: When is Ca²⁺ the culprit?
David P Wilson, University of Adelaide. Store-operated Ca²⁺ channels and vascular responsiveness.

AuPS Fatigue Mechanisms Limiting Exercise Performance Michael McKenna
& Mark Hargreaves

David Bishop, Victoria University. Fatigue during intermittent exercise: novel insights and real-world applications.
International speaker:
Markus Amann (University of Utah, USA). Neuromuscular fatigue: interactions between central and peripheral factors.

AuPS Skeletal muscle ROS: the good, the bad and the, well it kinda depends Glenn McConell

Tony Tiganis, Monash University. Skeletal muscle H2O2 and insulin sensitivity.
David James, The Garvan Institute. The role of ROS in insulin resistance.
Graham Lamb, La Trobe University. Effects of ROS /glutathionylation /S-nitrosylation on Ca-sensitivity and force, a balancing act.
Glenn McConell, Victoria University. Skeletal muscle ROS and glucose uptake during contraction.

Affil'n	Symposium	Chair	Speakers
ASB	Fundamentals of Biophysics - development of mathematical and computational methods	John Gehman	Philip Kuchel; University of Sydney and Singapore Bioimaging Consortium. Erythrocyte shape, metabolism and membrane transport - computations. Mehdi Mobli; University of Queensland, Institute of Molecular Bioscience. Fast acquisition of multidimensional NMR experiments by maximum entropy reconstruction of non-uniformly sampled data. David Szekely; Victor Chang Cardiac Research Institute. Toward the virtual heart: GPU accelerated interactive simulations of cardiac function. Adelle Coster; University of New South Wales. Vesicle docking and Delivery: Life in the TIRF zone.
ASB	Computational Studies on Biological and Synthetic Nanotubes	Shin-Ho Chung	Alan Mark, University of Queensland. The induction and stabilization oftransmembrane pores by peptides. Serdar Kuyucak, University of Sydney. Free energy simulations of Asp/Glu transporter GltPh. Ben Corry, University of Western Australia. Monitoring the conformational changes involved in MscL channel gating using FRET microscopy and simulation. Tamsyn Hilder, Australian National University. Mimicking biological ion channels using nanotubes. International speaker: Toby Allen, University of California Davis. Selective ion binding and its role in potassium channel selectivity.
Joint ASB/AuPS	Mechanisms of multidrug resistance - the role of transporters in human disease	Megan O'Mara & Chris McDevitt	Melissa Brown, Flinders University. Bacterial multidrug resistance pumps Rowena Martin, Australian National University. Multidrug resistance in the malarial parasite. Tony George, University of Technology Sydney. Perspectives on multi-drug resistance. International speakers: Richard Callaghan, Oxford University (also presenting as an ASB Plenary speaker). ABCB1, ABCG2 multidrug resistance structure-function relationships. Susan PC Cole, Queen’s University, Canada. Molecular mechanisms of drug sensitivity and resistance.
Joint ASB/AuPS	Skeletal muscle: the coupling of excitation to contraction	Nicole Beard	Brad Launikonis, University of Queensland. Voltage-dependent and -independent Ca²⁺ entry into skeletal muscle during excitation-contraction coupling. Travis Dutka, La Trobe University, Coupling and uncoupling of the voltage-sensors and Ca²⁺ release channels in skeletal fibres. International speaker: Robert Dirksen, University of Rochester Medical Center, NY (Also presenting as an ASB Plenary speaker). One is Enough: RyR1 Allele-Specific Gene Silencing in Mouse Models of MH and CCD
Joint ASB/AuPS	Imaging and dynamic microscopy (imaging of biological and biophysical processes)	Pierre Moens	Leann Tilley, La Trobe University, Imaging malaria parasite-infected erythrocytes using new high resolution modalities. Alpha Yap, Inst for Molecular Bioscience, University of Queensland, Cadherin dynamics and the cytoskeleton. Elizabeth Hinde, University of California, Irvine, In vivo pair correlation analysis of enhanced green fluorescent protein (EGFP) intra nuclear diffusion. International speakers: Enrico Gratton, University of California, Irvine. Detecting stem cell differentiation using fluorescence lifetime microscopy (FLIM) by the phasor approach. Michelle Digman, Optical Biology Core Facility, UCI. Molecular transport in cells by the pair correlation fluctuation method.
Joint ASB/AuPS	Calcium Signalling	Grigori Rychkov & Greg Barritt	International speakers: Richard Lewis, Stanford University, California. Title TBA Oleg Gerasimenko, School of Biosciences, Cardiff University, UK. Calcium regulation of apoptosis in pancreatic acinar cells. Andrew L. Miller, Hong Kong University of Science and Technology. The application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca²⁺ signaling during in vivo differentiation of slow muscle cells in zebrafish embryos.
Joint ASB/AuPS	Lipid Metabolism and disease: new insights from the lab to the clinic	Matthew Watt	Matthew Watt, Monash University. Circulating ceramides, inflammation and insulin resistance. Graeme Lancaster, Baker IDI. Dual but opposing roles for dsRNA-dependent protein kinase (PKR) in obesity and inflammation. Bronwyn Kingwell, Baker IDI. High density lipoproteins, diabetes and vascular function. Leonie Heilbronn, University of Adelaide. Calorie restriction vs. exercise: the fitness vs. fatness debate rages.
Joint ASB/AuPS	Ion channel modulation by peptide toxins	Ray Norton & David Adams	Glenn King, University of Queensland. Probing the interaction between psalmotoxin 1 and acid sensing ion channel 1a, an analgesic drug target. Mary Chebib, University of Sydney. Calcium, Vc1.1 and α9α10 nicotinic acetylcholine receptors David Adams, RMIT University. Analgesic conotoxins: modulation of voltage-gated calcium channels in pain pathways Ray Norton, Monash University. Conotoxins targeting voltage-gated sodium channels: Designing new analgesics International speaker: Bob French, University of Calgary Canada. Subverting the biological actions of Conus peptides to modulate physiological responses.
Joint ASB/AuPS	Molecular Physiology and Membrane Dynamics	Jens Coorssen & Peter Thorn	Frances Separovic, University of Melbourne. Membrane protein structure and function. Boris Martinac, Victor Chang Cardiac Research Institute mechanisms of mechanosensation. Ian Gibbins, Flinders University. Molecules in motion: imaging peptides, their receptors and diffusion models. Brett Garner, University of Wollongong. Targeting membrane lipids to modulate amyloid precursor protein processing. International speaker: Paul Dietl, University of Ulm, Germany. Molecular control of surfactant secretion in type 2 alveolar cells.
AuPS	Physiology Education	Simon Potocnik & Ann Sefton	keynote speaker TBA- Inaugural AuPS, Excellence in Physiology Education, Michael Roberts medallist. Yvonne M. Hodgson and J. Choate, Department of Physiology, Monash University. Using the Finapres to teach cardiovascular physiology to second year science students. Richard Guy, RMIT University. The KISS approach. How to develop an effective self directed e-learning application. David Saint, University of Adelaide. Lecture Attendance, Learning Style and Assessment Outcome in Physiology Students Steven Wiederman, University of Adelaide. The Human Physiology Writing Centre: Mentors helping students with their writing tasks
AuPS	Regulation of metabolic balance through co-ordination of central and peripheral signalling	Chen Chen	Michael Cowley, Monash University. Control of energy balance by nutrient sensing neurons. Frederik Steyn, University of Queensland. The importance of peripheral signals in regulating central control of GH secretion. International speaker: Jacque Epelbaum, INSERM-Molecular Neuroendocrinology Unit,  Paris France. Regulation of hypothalamic GHRH neuronal action by metabolic regulatory neurotransmitters
AuPS	New insights into the molecular architecture of the heart and their implications for heart disease	Yue-kun Ju & David Allen	Diane Fatkin, University of New South Wales. Mechanisms of contractile dysfunction in lamin A/C-deficient hearts. Angela Dulhunty, John Curtin School of Medical Research ANU. Proteins in the lumen of the SR determine cardiac RyR channel activity and structure of Ca²⁺ release units. Yue-kun Ju, University of Sydney. Distribution and functional role of IP3R receptors in mouse sino-atrial node. International speakers: Mark Boyett, University of Manchester, UK. The molecular architecture of the heart’s conduction system in health and disease. Mark Cannell, University of Auckland, NZ. A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes.
AuPS	Emerging Leaders in Developmental Physiology	Caroline McMillen & Helena Parkington	Karen Moritz, University of Queensland. Kidney development and regulation of blood pressure. Tim Moss, Monash University. Inflammation and lung development. Janna Morrison, University of South Australia. Early origins of cardiovascular disease: The heart of the matter. James Armitage, Monash University. Developmental origins of obesity related hypertension. Marianne Tare, Monash University. Early life environments and programming of the vascular phenotype
AuPS	Stress, disease and Ca²⁺ management: the cardiovascular challenge.	Lea M D Delbridge & David Saint	Derek Laver, University of Newcastle. Cardiac SR Ca²⁺ release channels and adrenergic stimulation. James R Bell, University of Melbourne. Cardiac ischemic stress: Ca²⁺ and sex scenarios. Marie L Ward, University of Auckland, NZ. Cardiomyopathies: When is Ca²⁺ the culprit? David P Wilson, University of Adelaide. Store-operated Ca²⁺ channels and vascular responsiveness.
AuPS	Fatigue Mechanisms Limiting Exercise Performance	Michael McKenna & Mark Hargreaves	David Bishop, Victoria University. Fatigue during intermittent exercise: novel insights and real-world applications. International speaker: Markus Amann (University of Utah, USA). Neuromuscular fatigue: interactions between central and peripheral factors.
AuPS	Skeletal muscle ROS: the good, the bad and the, well it kinda depends	Glenn McConell	Tony Tiganis, Monash University. Skeletal muscle H2O2 and insulin sensitivity. David James, The Garvan Institute. The role of ROS in insulin resistance. Graham Lamb, La Trobe University. Effects of ROS /glutathionylation /S-nitrosylation on Ca-sensitivity and force, a balancing act. Glenn McConell, Victoria University. Skeletal muscle ROS and glucose uptake during contraction.

Download the program here

For further information contact andrea.yool@adelaide.edu.au