AuPS ASB

AuPS/ASB Canberra 2005 Meeting

Programme

In the programme below, each presentation has, beside the time, the page number in volume 36 of the Proceedings. These numbers are links to the HTML versions of the pages. Each HTML page has a link to a corresponding PDF print version.

A PDF file of the abstracts for each platform and poster session can be accessed by click on the PDF symbol in the upper right of the programme block.

Links to the abstracts can also be found in the author index.

Tuesday 27 September 2005
0800 Ion Channel Modelling Workshop
Computer Laboratory, Copland G18
Australian National University
1730 Close

Huron and Michigan Rooms

Meeting Opening

1745 Opening remarks
Obituary Peter Gage
1830 Plenary Lecture - Francisco Bezanilla
Chair: David Adams
1P How does the membrane electric field gate an ion channel open and close? Francisco Bezanilla, Departments of Physiology and Anesthesiology. University of California at Los Angeles, Los Angeles, CA, U.S.A.
1930 Close
1930 Mixer

Wednesday 28 September 2005

Superior

Symposium 1: Ion Channel Gating

 PDF

Chair: Shin-Ho Chung

0845 2P The domains in the Na channel have specific functions Francisco Bezanilla and Baron Chanda, Departments of Physiology and Anesthesiology. University of California at Los Angeles, Los Angeles, CA, U.S.A.
0915 3P Modulation of potassium channel conformation and function by permeating ions Stephen J. Korn, Department of Physiology and Neurobiology University of Connecticut Storrs, Connecticut 06269 USA.
0945 4P The gating of mechanosensitive ion channels Boris Martinac, School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072.
1005 5P The mechanism of fast gating in ClC chloride channels B. Corry1, D. Bisset2 and S.H. Chung2, 1Chemistry. School of Biomedical, Biomolecular and Chemical Science, The University of Western Australia, Crawley, WA 6009, Australia and 2Research School of Physical Sciences and Engineering, The Australian National University Canberra, ACT 0200, Australia.
1025 6P Conformational changes associated with glycine receptor activation J.W. Lynch and R.L. Hawthorne, School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
1045 Close

Huron

Symposium 2: Functional Roles of Potassium Channels in the Vasculature

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Chair: Mike Hill

0845 Introduction and overview: Mike Hill
0850 7P Endothelium-dependent vasodilatation: Fundamental role of SKCa and IKCa potassium channels C.J. Garland, Vascular Pharmacology Group, Department of Pharmacy & Pharmacology, University of Bath, Bath BA2 7AY, U.K.
0925 8P Functional effects of vascular KIR channels C.G. Sobey, Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia. (Introduced by M. Hill)
0935 9P Kv as a target for nitroxyl anion (NO−)-mediated vasodilatation B.K. Kemp-Harper and J.L. Favaloro, Department of Pharmacology, Monash University, VIC 3800, Australia. (Introduced by M. Hill)
1005 10P The smooth muscle BKCa potassium channel and its interaction with arteriolar myogenic tone T.V. Murphy1, Y.T. Hwang1, H. Ding2, N. Kotecha2 and M.A. Hill1, 1Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia and 2Division of Biosciences, School of Medical Sciences, RMIT University, VIC 3083, Australia.
1025 11P Potassium channels in vascular dysfunction C.R. Triggle1, A. Ellis2, L. Ceroni3, W. Wiehler3 and H. Ding1, 1School of Medical Sciences, RMIT University, Melbourne, VIC, Australia, 2Division of Chinese Medicine, School of Health Sciences, RMIT University, Melbourne, VIC, Australia and 3Smooth Muscle Research Group, University of Calgary, Canada. (Introduced by Michael Hill)
1045 Close
1045-1115 Morning Tea

Free Communications 1: Exercise Physiology

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Chair: David Allen

1115 12P Sudomotor responses during isometric exercise appear to be intensity- and muscle mass-dependent C.J. Gordon, C.D. Haley, J.N. Caldwell and N.A.S. Taylor, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia.
1130 13P Hydration indices in exertional heat stress A.T. Garrett1,2, N.G. Goossens1, N.J. Rehrer1, M.J. Patterson3 and J.D. Cotter1, 1School of Physical Education, University of Otago, Dunedin, New Zealand, 2College of Education, University of Canterbury, Christchurch, New Zealand, and 3Defence Science and Technology Organisation, Melbourne, Australia.
1145 14P Plasma ammonia responses during heavy-intensity constant-load cycling in young and older individuals S. Sabapathy, D.A. Schneider and N.R. Morris, School of Physiotherapy and Exercise Science, and Heart Foundation Research Centre, Gold Coast campus, Griffith University, Southport, QLD 4215, Australia.
1200 15P Abnormal muscle Na+,K+-pumps, plasma K+, and exercise limitation in renal failure patients A.C. Petersen1, M.J. Leikis2, K.T. Murphy1, J.A. Leppik1, X. Gong1, A.B. Kent2, L.P. McMahon2 and M.J. McKenna1, 1Muscle, Ions and Exercise Group, Centre for Ageing, Rehabilitation, Exercise and Sport, School of Human Movement, Recreation and Performance, Victoria University, Melbourne, VIC 8001, Australia and 2Department of Nephrology, Royal Melbourne Hospital, Department of Medicine, University of Melbourne, Melbourne, VIC 3052, Australia.
1215 16P The effect of eccentric exercise on plasma K+ regulation and skeletal muscle Na+,K+-ATPase activity and content J.A. Bennie1, C.A. Goodman1, M.J. Leikis2 and M.J. McKenna1, 1Muscle, Ions and Exercise Group, School of Human Movement, Recreation and Performance, Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, PO Box 14428, Melbourne, VIC 8001, Australia and 2Department of Nephrology, Royal Melbourne Hospital, Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
1230 17P N-acetylcysteine infusion enhances skeletal muscle Na+,K+-ATPase activity and plasma K+ regulation, and delays fatigue, during prolonged submaximal exercise in well-trained individuals C.A. Goodman1, I. Medved1, M.J. Brown2, A.R. Bjorksten3, K.T Murphy1, A.C Petersen1, S. Sostaric1, X. Gong1 and M.J. McKenna1, 1Muscle, Ions & Exercise Group, Centre for Ageing, Rehabilitation, Exercise and Sport, School of Human Movement, Recreation and Performance, Victoria University, PO Box 14428, Melbourne, VIC 8001, Australia, 2Department of Anaesthesia, Austin Health, Heidelberg, VIC, Australia and 3Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, VIC, Australia.

Free Communications 2: Ion channels

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Chair: Peter Barry

1115 18P Investigating the mechanism of proton transfer through the bacterial ClC transporter M. O’Mara, J. Yin, M. Hoyles and S.H. Chung, Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200, Australia.
1130 19P An electrostatic basis for valence selectivity in cationic channels T. Vora1, B. Corry2, and S.H. Chung1, 1The Department of Theoretical Physics, RSPhysSE, The Australian National University, Canberra, ACT 0200, Australia and 2Chemistry, School of Biomedical and Chemical Science, The University of Western Australia, Crawley, WA 6009, Australia.
1145 20P A current source and a cation conductance are components of an electrical circuit connected across the plasma membrane of the malaria parasite Plasmodium falciparum R.J. W. Allen, K.J. Saliba and K. Kirk, School of Biochemistry and Molecular Biology, Linnaeus Way, Australian National University, Canberra, ACT 0200, Australia.
1200 21P Role of protein flexibility in gramicidin A channel permeability Turgut Bastug, School of Physics, University of Sydney, NSW 2006, Australia.
1215 22P Ca2+ influx through store-operated Ca2+ channel in mouse sinoatrial node Y.K. Ju1, H. Chaulet2, R.M. Graham2 and D.G. Allen1, 1School of Medical Sciences, University of Sydney, NSW 2006, Auatralia and 2Victor Chang Cardiac Research Institute, NSW 2010, Australia.
1230 23P A hydrogen peroxide insult causes sustained alteration in the sensitivity of the L-type Ca2+ channel to β-adrenergic receptor stimulation in ventricular myocytes L.C. Hool, H.M. Viola and P.G. Arthur, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia.
1245-1345 Lunch

Superior

Plenary Lecture - Nigel Unwin

Chair: Louise Tierney

1345 24P Structure and gating mechanism of the nicotinic acetylcholine receptor N. Unwin, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Superior

Free Communications 3: Ligand-Gated Ion Channels

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Chair: Louise Tierney

1445 25P Analysis of a GABAAγ2 (R43Q) knock-in mouse model of familial epilepsy S. Petrou, H. Tan, P. Davies and S. Murphy, Howard Florey Institute, The University of Melbourne, VIC 3010, AUSTRALIA.
1505 26P The receptor-associated protein, rapsyn, and regulation of postsynaptic acetylcholine receptor packing density and turnover at the neuromuscular synapse W.D. Phillips and O.L. Gervásio, Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW 2006, Australia.
1525 27P Functional consequences of clustering GABAA receptors M.L. Tierney, T. Luu, A.E. Everitt, P.W. Gage, Membrane Physiology & Biophysics Group, The John Curtin School of Medical Research, The Australian National University, Canberra 0200, Australia.
1545 28P The charge of the P-loop glutamate controls cation-anion selectivity in CNG channels W. Qu1, A.J. Moorhouse1, M. Chandra1, K.D. Pierce2, T.M. Lewis1 and P.H. Barry1, 1Dept of Physiology and Pharmacology, School of Medical Sciences, The University of New South Wales, NSW 2052, Australia and 2Neurobiology Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
1600 29P Structure and dynamics of the periplasmic loop of the MscL mechanosensitive channel studied by electron paramagnetic resonance spectroscopy G. Meyer1,2,3, E. Perozo2 and B. Martinac1,3, 1School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia and 2Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22906, USA. 3(Present address: School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia).

Huron

Free Communications 4: Skeletal Muscle Regulation: From Molecular Mechanism to Physiology

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Chair: Brett Cromer, David Allen

1445 30P Calcium-phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca2+ release in mammalian skeletal muscle T.L. Dutka, L. Cole and G.D. Lamb, Department of Zoology, La Trobe University, Victoria 3086, Australia.
1500 31P Digoxin effects on muscle strength, fatigue and K+ fluxes during exercise in healthy young adults M.J. McKenna1, S. Sostaric1, M.J. Brown2, C.A. Goodman1, X. Gong1, A.C. Petersen1, J. Aw3, J. Leppik1, C.H. Steward1, S.F. Fraser4, R.J. Snow5 and H. Krum3, 1Muscle, Ions and Exercise Group, School of Human Movement, Recreation and Performance, Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, PO Box 14428, Melbourne, VIC 8001, Australia, 2Department of Anaesthesia, Austin Health, Heidelberg, VIC, Australia, 3Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, Australia, 4School of Medical Sciences, RMIT University, Bundoora, VIC, Australia and 5School of Exercise Science and Nutrition, Deakin University, Burwood, VIC, Australia.
1515 32P The peak tetanic force-[K+]o relationship in mouse fast- and slow-twitch muscle: modulation with [Na+]o or [Ca2+]o S.P. Cairns, Division of Sport & Recreation, Auckland University of Technology, Auckland 1020, New Zealand.
1530 33P The effect of dithiothreitol (DTT) application on isolated mouse muscle fatigued at 37°C T.R. Moopanar and D.G. Allen, School of Medical Sciences, University of Sydney F13, NSW 2006, Australia.
1545 34P Cytoplasmic ATP-sensing CBS domains regulate gating of skeletal muscle ClC-1 chloride channels B. Bennetts1, G.Y. Rychkov2, H-L. Ng1, C.J. Morton1, D. Stapleton3, M.W. Paarker1 and B.A. Cromer1, 1St. Vincent’s Institute, Fitzroy, VIC 3065, Australia,2 The University of Adelaide, Adelaide, SA 5005, Australia and 3Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
1600 35P Modelling diffusive O2 supply to isolated muscle preparations C.J. Barclay, Muscle Energetics Laboratory, School of Physiotherapy & Exercise Science, Griffith University Gold Coast, PMB50 Gold Coast Mail Centre, Gold Coast, Queensland 9726, Australia.

Superior

1615 - Poster Session, Afternoon Tea and Drinks

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Ion channel structure and function
1 36P Effects of gadolinium and static magnetic fields on MscL channel activity E. Petrov, Z.-W. Liu and B. Martinac, School of Biomedical Sciences, University of Queensland, St Lucia, 4072 Australia.
2 37P Conformational changes involved in MscL channel gating measured using FRET spectroscopy B. Corry1, P. Rigby2 and B. Martinac3, 1Chemistry, School of Biomedical, Biomolecular and Chemical Science, 2Biomedical Imaging and Analysis Facility and 3School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA 6009, Australia.
3 38P C-terminal charged cluster of the mechanosensitive channel MscL, RKKEE, functions as a pH sensor Anna Kloda and Boris Martinac, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072 Australia.
4 39P The effects of eriochrome cyanine R on the mechanosensitive channels of E. coli T. Nguyen1,2, B. Clare2, L. Hool2 and B. Martinac3, 1School of Medicine and Pharmacology, University of Western Australia, WA 6009, Australia2, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, WA 6009, Australia and 3School of Biomedical Sciences, University of Queensland, QLD 4072, Australia.
5 40P Mutations within the selectivity filter of the NMDA receptor channel influence voltage-dependent block by extracellular 5-Hydroxytryptamine Anna Kloda and David Adams, School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.
6 41P Ion selectivity of glycine receptors with mutations of charged residues in the intracellular portals T.M. Lewis1, Sugiharto1, J.A. Peters2, J.J. Lambert2, P.H. Barry1 and A.J. Moorhouse1, 1School of Medical Sciences, The University of New South Wales, NSW 2052, Australia and 2Department of Pharmacology and Neuroscience, The University of Dundee, Dundee DD1 9SY, United Kingdom.
7 42P A molecular determinant of tropisetron inhibition of the glycine receptor Cl- channel Z. Yang, A.D. Ney and J.W. Lynch, School of Biomedical Sciences, University of QLD, Brisbane QLD 4072, Australia.
8 43P Subunit-specific inhibition of recombinantly expressed glycine receptors by ginkgolides and bilobalide R.L. Hawthorne and J.W. Lynch, School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.
9 44P Crosslinking of α1β1 GABAA receptor subunits via cysteines introduced into the transmembrane domain T.I. Webb, Z. Yang and J.W. Lynch, School of Biomedical Sciences, University of QLD, Brisbane QLD 4027, Australia.
10 45P Etomidate alters the single-channel properties of GABAA receptors in newborn rat hippocampal neurons V.A.L. Seymour, P.W. Gage and M.L. Tierney, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
11 46P GABAA αβ receptors open spontaneously when the conserved M2 leucine 9′ residue is mutated to a threonine T.L. Luu, M.L. Tierney and P.W. Gage, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, ACT 2601, Australia.
12 47P GABARAP influences the conductance of recombinant GABAA channels A.B. Everitt, M.L. Tierney and P.W. Gage, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
13 48P C-Terminal peptide of M protein from dengue virus (DVM-C) forms ion channels A. Premkumar, C.R. Horan and P.W. Gage, Division of Molecular Biosciences, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT 2601, Australia.
14 49P The role of the M1-P1 loop in acid sensitive two-pore domain potassium (TASK) channel regulation Catherine E. Clarke1,2, Alistair Mathie3 and Jamie I. Vandenberg1,2, 1St Vincent's Hospital Clinical School, University of New South Wales, Victoria Road, Darlinghurst NSW 2010, Australia, 2Electrophysiology and Biophysics Unit, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia and 3Department of Biological Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
15 50P Structural studies of chloride intracellular ion channel proteins A.V. Mynott1, D.R. Littler1, P.M.G. Curmi1, L.J. Brown2 and S.N. Breit3, 1School of Physics, University of New South Wales, NSW 2052, Australia, 2Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia and 3St Vincent's Hospital, Sydney, NSW 2010, Australia.
Biomolecular structure and dynamics
16 51P Photochemical behaviour and Na+,K+-ATPase sensitivity of voltage-sensitive styrylpyridinium fluorescent membrane probes S. Amoroso1, V.V. Agon1, T. Starke-Peterkovic1, M.D. McLeod1, H.-J. Apell2, P. Sebban3 and R.J. Clarke1, 1School of Chemistry, University of Sydney, NSW 2006, Australia, 2Faculty of Biology, University of Constance, D-78434 Constance, Germany and 3Laboratory of Physical Chemistry, UMR 8000, University of Paris XI, Orsay 91405, France.
17 52P Applications of styrylpyridinium dyes in elucidating ion-transport mechanisms in plant cells S. Amoroso1, R.J. Clarke2, A. Larkum1 and R. Quinnell1, 1School of Biological Sciences, University of Sydney, NSW 2006, Australia and 2School of Chemistry, University of Sydney, NSW 2006, Australia.
18 53P The crystal structure of Pichia pastoris lysyl oxidase at 1.23Å reveals a lysine-lysine covalent cross-link, dehydrolysinonorleucine A.P. Duff1, A.E. Cohen2, P.J. Ellis2, D.B. Langley1, D.M. Dooley3, H.C. Freeman1 and J.M. Guss1, 1School of MMB, University of Sydney, NSW 2006, Australia, 2Stanford Synchrotron Radiation Laboratory, CA, USA and 3Chemistry and Biochemistry, Montana State University, Bozeman MT, USA.
19 54P Molecular dynamics study of conformational changes in human serum albumin by binding of fatty acids S. Fujiwara and T. Amisaki, Department of Biological Regulation, Faculty of Medicine, Tottori University, 86 Nishi-machi, Yonago, 683-8503, Japan.
20 55P NMR probes of red cell deformation P.W. Kuchel, B.E. Chapman, D.J. Philp and W.A. Bubb, School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
21 56P Current-voltage analysis of response to salt stress by salt-tolerant and salt-sensitive charophyte cells Mary J. Beilby and Virginia A. Shepherd, Biophysics, School of Physics, University of NSW, NSW 2052, Australia.
22 57P Oxygen evolution in chimeric spinach photosystem II with cyanobacteria manganese stabilising protein Adele Williamson, Warwick Hillier, Reza Razeghifard and Tom Wydrzynski, Photobioenergetics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia.
23 58P The role of an oil droplet lens in vision enhancement L. Fischer1, M. Vorobyev2, A. Zvyagin1 and T. Plakhotnik1, 1Department of Physics, University of Queensland, QLD 4072, Australia and 2Vision Touch and Hearing Research Centre, University of Queensland, QLD 4072, Australia.
24 59P Circular dichroic spectra of the N-terminal region of cardiac myosin binding protein – C C.E. Oakley1, L.J. Brown2 and B.D. Hambly1, 1Department of Pathology, University of Sydney, NSW 2006, Australia and 2Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia.
25 60P Changes in mechanical properties of live cell wall during turgor regulation monitored by atomic force microscopy E.M. Mahomudally1, M.J. Beilby2, V. Shepherd2 and A.R. Moon1, 1Department of Applied Physics, University of Technology, Sydney, NSW 2007, Australia and 2Biophysics Department, School of Physics, University of New South Wales, Kensington, NSW 2052, Australia. (Introduced by M.J. Beilby)
Cardiac muscle and Skeletal muscle
26 61P Effect of temperature on stretch-induced cardiac action potential shortening in the rat heart: involvement of TREK-1 D.R. Kelly, L. Mackenzie and D.A. Saint, Department of Physiology, University of Adelaide, SA 5005, Australia.
27 62P Immunohistochemical identification of stretch-sensitive two-pore-potassium (TREK) channels in the human heart S.Y. Yuan, H.P. Zhu and D. Saint, Department of Physiology, School of Molecular & Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia.
28 63P More than one type of stretch activated channel contributes to the action potential duration in guinea pig L. Mackenzie, D.R. Kelly and D.A. Saint, Department of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, SA 5000, Australia.
29 64P Fatty acid composition of red blood cell membranes as a marker of human heart membrane phospholipid fatty acids Mandy L Theiss1, Salvatore Pepe2 and Peter L. McLennan1, 1Smart Foods Centre, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia and 2Cardiac Surgical Research Lab, Alfred Hospital & Baker Medical Research Institute, Prahran, VIC 3181, Australia.
30 65P Confocal Ca2+ imaging of mouse sinoatrial node Y.K. Ju1, D.G. Allen1 and M.B. Cannell2, 1School of Medical Sciences, University of Sydney, NSW 2006, Australia and 2The Faculty of medical and Health Sciences, University of Auckland, Auckland, New Zealand.
31 66P Reactive oxygen species generated from the mitochondria and not NAD(P)H-oxidase regulate L-type Ca2+ channel function during acute hypoxia in ventricular myocytes L.C. Hool, H.M. Viola, C.A. Di Maria and P.G. Arthur, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, WA 6009, Australia.
32 67P Eccentric damage is accentuated in aged dystrophin-deficient EDL muscles from dystrophic mice (MDX) S. Chan and S.I. Head, School of Medical Sciences, UNSW, NSW 2052, Australia.
33 68P Phosphorylation of CSQ affects Ca2+ binding and interactions with anchoring protein junctin N.A. Beard1, S. Cheung1, L. Wei1, M. Varsànyi2 and A.F. Dulhunty1, 1John Curtin School of Medical Research, ANU, Canberra, ACT 0200, Australia and 2Institut für Physiologische Chemie, Ruhr Universität, Bochum, Germany.
34 69P A calsequestrin polymer is necessary for the Ca2+ binding protein to regulate RyR channels L. Wei, N.A. Beard and A.F. Dulhunty, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
35 70P Digoxin and exercise effects on Na+,K+-pump activity, content, isoform gene and protein expression in human skeletal muscle X. Gong1, A. Petersen1, S. Sostaric1, C. Goodman1, D. Cameron-Smith2, R. Snow2, K. Murphy1, K. Carey2, J. Aw3, H. Krum3 and M. McKenna1, 1School of Human Movement, Recreation and Performance, Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, Melbourne, VIC 8001, Australia, 2School of Exercise Science and Nutrition, Deakin University, Melbourne, VIC 3125, Australia and 3Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, Australia.
Nervous system
36 71P Reduced long-term depression is recovered in aging mdx cerebellar Purkinje cells J.L. Anderson, S.I. Head and J.W. Morley, School of Medical Sciences, UNSW, NSW 2052, Australia.
37 72P Differential action of ω-conotoxins CVID and CVIB on voltage-gated calcium channels in rat sensory neurons L.M. Motin, R.J. Lewis and D.J. Adams, School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
38 73P Evidence from collision experiments that onset chopper neurons in the guinea pig cochlear nucleus receive excitatory input from centrifugal collaterals D. Robertson and W.H.A.M. Mulders, The Auditory Laboratory, Discipline of Physiology, School of Biomedical Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia.
39 74P P2Y receptor activation inhibits the formation and proliferation of primary mouse sub-ventricular-derived neurospheres M.R. Stafford, P.F. Bartlett and D.J. Adams, School of Biomedical Sciences and The Queensland Brain Institute, University of Queensland, Brisbane QLD 4072 Australia.
Membrane transport and its regulation
40 75P Protein kinase A inhibits cell growth induced by overexpression of IK channels C.J. Fowler, K. Ngui, B. Hunne, D. Poole, J.B. Furness and C.B. Neylon, Department of Anatomy and Cell Biology, The University of Melbourne, VIC 3010, Australia.
41 76P Post-transcriptional regulation of CFTR protein expression by 5′untranslated region encoded regulatory elements S-J. Conroy, W.L Davies and A.E.O. Trezise, School of Biomedical Science, The University of Queensland, QLD 4072, Australia.
42 77P Nedd4-2, CLC-5 and albumin endocytosis in the proximal tubule: a role for SGK-1? D.H. Hryciw1, J. Ekberg1, A. Lee1, I.L. Lensink2, S. Kumar2, W.B. Guggino3, D.I. Cook4, C.A. Pollock5 and P. Poronnik1, 1School of Biomedical Sciences, University of QLD, Brisbane, QLD 4072, Australia, 2Hanson Institute, IMVS, Adelaide, SA 5000, Australia, 3Department of Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA, 4Department of Physiology, University of Sydney, NSW 2006 Australia, and 5Kolling Institute, RNSH, University of Sydney, NSW 2065, Australia.
43 78P Na+ H+ exchanger regulatory factor 2 (NHERF-2) is a scaffold for the plasma membrane Ca2+ ATPase (PMCA) W.A. Kruger1, G.R. Monteith2, L. Tongpao1 and P. Poronnik1, 1School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia and 2School of Pharmacy, The University of Queensland, St Lucia, QLD 4072, Australia.
44 79P NHERF1 - a novel scaffold protein for the astroglial glutamate transporter GLAST A. Rayfield1, A. Lee1, D. Pow2, D. Hryciw1, T.A. Ma1, S. Broer3, C. Yun4 and P. Poronnik1, 1School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia,2 Department of Anatomy, University of Newcastle, NSW 2308, Australia,3 Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia and 4Department of Medicine, Emory University, Atlanta, Georgia 30322, USA.
45 80P Molecular cloning and characterisation of the mouse ‘system IMINO’ transporter S. Kowalczuk1, A. Bröer1, M. Munzinger1, N. Tietze1, K. Klingel2 and S. Bröer1, 1School of Biochemistry & Molecular Biology, Australian National University, Canberra, ACT 0200, Australia and 2Department of Molecular Pathology, University of Tübingen, 72076 Tübingen, Germany.
46 81P Increased acetaminophen hepatotoxicity in the NaS1 sulphate transporter null mouse S. Lee, P.A. Dawson and D. Markovich, School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
Nutrition
47 82P The influence of dietary fish oil and exercise upon oxidative status biomarkers in a rat model R. Henry, A.J. Owen and P.L. McLennan, Smart Foods Centre, Department of Biomedical Science, University of Wollongong, NSW 2522, Australia.
Education
48 83P Simulation of visual processing in retinal ganglion cells M. Watson,1 G. Holmes,1 T. Byrne2 and S. Cornford,1 1Department of Biological & Physical Sciences, Faculty of Sciences, 2Faculty of Engineering and Surveying, University of Southern Queensland, Toowoomba, QLD 4350, Australia.

Superior

AuPS Invited Lecture - Angela Dulhunty

Chair: David Adams

1800 84P Excitation-contraction coupling from 1969 to 2005 A.F. Dulhunty, Division of Molecular Bioscience, John Curtin School of Medical Research, Building 54, Off Mills Rd, Australian National University, ACT 0200, Australia.
1900- Student Function

Thursday 29 September 2005

Superior

Symposium 3: Physiology Teaching in the 21st Century: Trends, Challenges and Innovations

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Chair: Kay Colthorpe and Hardy Ernst

0845 85P Challenges facing physiology educators in the 21st century Ann Sefton, Faculty of Medicine, University of Sydney, NSW 2006, Australia.
0915 86P Research led teaching and learning in physiology R.E. Kemm, Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia.
0945 87P Problem-based learning (PBL): A novel and effective approach for teaching research skills by addressing contemporary research problems in physiology J. Schwartz1 and P. Buckley1,2, 1Discipline of Physiology, School of Molecular and Biomedical Science, Univeristy of Adelaide, Adelaide SA, Australia and 2School of Pharmacy & Medical Sciences, University of South Australia, Adelaide SA, Australia. (Introduced by Michael Roberts)
1015 88P Improving learning outcomes for students in Clinical Physiology C.R Dallemagne, School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia.
1045 Close

Huron

Symposium 4: Membrane Protein Structure and Interactions

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Chair: Frances Separovic

0845 89P Seeing spots: miscibility transitions in lipid/cholesterol membranes S.L. Keller and S.L. Veatch, Departments of Chemistry and Physics, University of Washington, Seattle, WA 98195-1700, U.S.A. (Introduced by Frances Separovic)
0925 90P Role of the plasma membrane in amyloid formation and toxicity M.I. Aguilar1, X. Hou1, S. Subasinghe1, A. Mechler2, K. Hall1, L. Martin2 and D.H. Small1, 1Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia and 2School of Chemistry, Monash University, Clayton, VIC 3800, Australia.
0950 91P Are chloride intracellular ion channel proteins (CLICs) really channels? Exploring their membrane structure L.J. Brown1, D.R. Littler2, A. Mynott2, S.J. Harrop2, S.N. Breit3, M. Mazzanti4 and P.M.G. Curmi2, 1Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia, 2School of Physics, University of New South Wales, NSW 2052, Australia, 3Centre for Immunology, St Vincent’s Hospital, Sydney NSW 2010, and 4University or Rome, La Sapienza, Roma, Italy.
1015 92P Structure and dynamics of cellular components using fluorescence and X-ray diffraction techniques Leann Tilley and Nick Klonis, Department of Biochemistry, La Trobe University, Bundoora, VIC 3083, Australia.
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1045-1105 Morning Tea

Superior

Symposium 5: Regulation of Membrane Transport

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Chair: David Adams

1105 93P The canonical transient receptor potential channel 1 is an essential structural component of the mechanosensitive calcium permeable channel in vertebrate cells O.P. Hamill1, R. Maroto1, A. Kurosky2, T.G. Wood2, A. Raso3 and B. Martinac3, 1Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, U.S.A., 2Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, U.S.A. and 3Department of Pharmacology, University of Western Australia, Crawley, WA, Australia.
1135 94P Sensing pressure with K2P channels Eric Honore, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, Institut Paul Hamel, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
1205 95P Varieties of mechanotransduction: the cytoskeletal stress fibre as a force transmitter and a mechanosensor Masahiro Sokabe1, Kimihide Hayakawa2 and Hitoshi Tatsumi1, 1Department of Physiology, Nagoya University Graduate School of Medicine, Nagoya, 464-8558, Japan and 2ICORP/SORST Cell Mechanosensing, JST, Nagoya, 464-8550, Japan.
1235 96P Role of tryptophan residues in ion channel function Amitabha Chattopadhyay, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
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Symposium 6: Membrane Associated Proteins that Regulate Muscle Contraction

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Chair: Angela Dulhunty

1105 97P From DHPR to RyR and back again: What lies along the way? Kurt Beam, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, U.S.A.
1150 98P Regulation of ryanodine receptors from skeletal and cardiac muscle by components of the cytoplasm and lumen D.R. Laver, School of Biomedical Sciences, University of Newcastle, and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia.
1215 99P Structural and functional characterisation of the interaction of the dihydropyridine receptor II-III loop with the ryanodine receptor M.G. Casarotto, Y. Cui, Y. Karunasekara, P.J. Harvey, N. Norris, P.G. Board and A.F Dulhunty, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, ACT 0200, Australia.
1240 100P ClC-1 chloride channel - matching its properties to a role in skeletal muscle G. Rychkov, School of Molecular and Biomedical Science, The University of Adelaide, ADELAIDE, 5005.
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1305-1350 Lunch

Superior

Plenary Lecture D. Peter Tieleman

Chair: Boris Martinac

1350 101P Pores, channels and transporters: computational studies of membrane transport Peter Tieleman, Department of Biological Sciences, University of Calgary, 2500 Unniveristy Drive NW, Calgary AB, T2N 1N4, Canada.

Free Communications 5: Cardiac muscle

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Chair: Lea Delbridge

1450 102P Does lignocaine increase the chance of survival from massive heart attack? S.M. Weiss and P.W. Gage, John Curtin School of Medical Research, Australian National University, ACT 0200, Australia.
1505 103P Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes Bonny Honen, Rebecca Dalton, Dirk van Helden and Derek Laver, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia.
1520 104P Abnormal calcium transients and calcium handling protein expression in cardiomyocytes from mdx (dystrophic) mice I.A. Williams and D.G. Allen, Institute for Biomedical Research, School of Medical Sciences, University of Sydney F13, NSW 2006, Australia.
1535 105P Mechanisms underlying the stretch-dependent slow inotropic response in isolated mouse myocardium M.L. Ward1 and D.G. Allen2, 1Department of Physiology, University of Auckland, New Zealand and 2School of Medical Sciences, University of Sydney F13, NSW 2006, Australia.
1550 106P Salutary effects of pyruvate are more evident in female than male glut4-deficient mouse hearts C.E. Huggins1, J. Favaloro2, J. Proietto2, S. Pepe3 and L.M.D. Delbridge1, 1Department of Physiology, University of Melbourne, VIC 3010, Australia, 2Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australia and 3Alfred Hospital and Baker Heart research Institue, Prahran, VIC 3181, Australia.
1605 107P The angiotensin type 2 receptor prevents cell death in neonatal cardiomyocytes of the hypertrophic heart rat E.R. Porrello1,2, A. D'Amore2, C.L. Curl1, S.B. Harrap1, W.G. Thomas2 and L.M.D. Delbridge1, 1Department of Physiology, The University of Melbourne, VIC 3010, Australia and 2Baker Heart Research Institute, Prahran, VIC 3004, Australia.

Free Communications 6: Cellular signaling

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Chair: Craig Neylon

1450 108P Analyses of the actin cytoskeleton using fluorescence resonance energy transfer (FRET) C.G. dos Remedios1, D. Chhabra1, I. Dedova1, D. Safer2 and E DeLaCruz3, 1Institute for Biomedical Research F13, University of Sydney, NSW 2006, Australia, 2Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, PA, 19104, USA, and 3Department of Molecular Biophysics & Biochemistry, Yale University, 266 Whitney Ave, PO Box 208114, New Haven, CT, 06520-8114, USA.
1505 109P Profilin binding to sub-micellar concentration of polyphosphoinositides PI(4,5)P2 and PI(3,4,5)P3 P.D.J. Moens, School of Biological, Biomedical and Molecular Sciences, The University of New England, Armidale, NSW 2351, Australia.
1520 110P Phospholipase Cγ is essential for activation of store-operated Ca2+ channels in liver cells T. Litjens1, T. Nguyen1, E. Aromataris1, M. Roberts1, G. Barritt2 and G. Rychkov1, 1School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA 5005 and 2School of Medicine, Flinders University of South Australia, G.P.O. Box 2100, Adelaide, SA 5001, Australia.
1535 111P Distinct characteristics of exocytosis in mouse pancreatic acinar cells Peter Thorn1, Olga Larina1 and Ian Parker2, 1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD and 2Department of Neurobiology and Behavior, University of California Irvine, CA 92697, USA.
1550 112P Synchronization of Ca2+ oscillations through interaction of intracellular Ca2+ stores and L-type Ca2+ channels M.S. Imtiaz, J. Zhao, K. Hosaka and D.F. van Helden, The Neuroscience Group, School of Biomedical Sciences, Faculty of Health and Medical Sciences, The University of Newcastle, NSW 2308, Australia.
1605 113P Characterization of the of the electrical activity underlying spontaneous contractions in the mouse ureteropelvic junction R.J. Lang, B. Zoltkowoski, J. Hammer, W. Meeker, I. Wendt and H. Parkington, Department of Physiology, Monash University, Clayton, Vic 3800, Australia.
1620-1635 Afternoon Tea

Free Communications 7: Muscle physiology

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Chair: Derek Laver

1635 114P Active metabolism of mouse papillary muscle C. Widén and C.J. Barclay, Muscle Energetics Laboratory, Heart Foundation Research Centre, School of Physiotherapy & Exercise Science, Griffith University, PMB50 Gold Coast Mail Centre, Gold Coast, QLD 9726, Australia.
1650 115P Functional and electrophoretic identification of two Troponin C isoforms in toad skeletal muscle fibres B. O'Connell, R. Blazev and G.M.M. Stephenson, School of Biomedical Sciences, Victoria University, Melbourne, VIC 3011, Australia.
1705 116P X-ray diffraction analysis of the effects of myosin chain-2 phosphorylation on the structure of fast skeletal muscle fibres Joseph F.Y. Hoh1, Maki Yamaguchi2, Masako Kimura2, Shigeru Takemori2 and Naoto Yagi3, 1Department of Physiology and Institute for Biomedical Research, The University of Sydney, NSW 2006, Australia, 2Department of Physiology, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan and 3Japan Synchrotron Radiation Research Institute (JASRI), Sayo-gun 679-5198, Japan.
1720 117P Calpain-1 and calpain-3 are not autolysed with exhaustive exercise in humans R.M. Murphy1, R.J. Snow2 and G.D. Lamb1, 1Department of Zoology, La Trobe University, VIC 3086, Australia and 2School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia.
1735 118P Increased fatigue resistance in EDL muscle of the obese mouse is associated with an increase in the proportion of hybrid IIB+IID fibres R. Blazev1, J.G. Kemp1,2, D.G. Stephenson3 and G.M.M. Stephenson1, 1School of Biomedical Sciences, Victoria University, VIC 3011, Australia, 2School of Exercise Science, Australian Catholic University, VIC 3065, Australia and 3Department of Zoology, La Trobe University, VIC 3083, Australia.
1745 119P Insulin-like growth factor-I gene transfer by electroporation enhances skeletal muscle regeneration and function after injury J.D. Schertzer and G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia.

Free Communications 8: Biophysics

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Chair: Paul Smith

1635 Introduction by Boris Martinac
1645 ASB Robertson Lecture (TBA)
1715 120P Bicarbonate is not a physiological substrate of Photosystem II I.L. McConnell, W. Hillier and T. Wydrzynski, Photobioenergetics Group, The Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia.
1730 121P Spectra of reef fish – a physics approach to colourful patterns Misha Vorobyev and Justin Marshall, Vision Touch and Hearing Research Centre, School of Biomedical Sciences, University of Queensland, QLD 4072, Australia.
1745 122P Resonances of the human vocal tract and some of their uses John Smith and Joe Wolfe, School of Physics, University of New South Wales, NSW 2052, Australia.
1800 Close
1900 - 2200 Conference Dinner - Australian National Museum

Friday 30 September 2005

Superior

Free communications 9: Education

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Chair: Ann Sefton

0845 123P Enhancing the first-year experiences of undergraduate students enrolled in large classes Roger W. Moni, Karen B. Moni, Lesley Lluka and Philip Poronnik, School of Biomedical Sciences The University of Queensland, St. Lucia, 4072, Brisbane, Australia.
0900 124P Creating an effective learning community in a large-class service teaching physiology course H. Ernst and K. Colthorpe, School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.
0915 125P The place of physiology in an integrated medical curriculum T.O. Neild, Department of Human Physiology, Flinders University, GPO Box 2100, Adelaide SA, 5001. Australia.
0930 126P Using a student-centred approach to enhance understanding of the physiology of metabolism and energy balance K.L. Colthorpe and H.G.G. Ernst, School of Biomedical Sciences, University of Queensland, St Lucia, Queensland 4072, Australia.
0945 127P Student perceptions and use of pre-specified criteria in constructing complex concept maps in physiology Roger W. Moni, Eileen Beswick, Alex Forrest and Karen B. Moni, School of Biomedical Sciences The University of Queensland, St. Lucia, QLD 4072, Australia.
1000 128P The opinion editorial – a novel assessment task in final year physiology Deanne Hryciw, Philip Poronnik and Roger W. Moni, School of Biomedical Sciences The University of Queensland, St. Lucia, QLD 4072, Australia.

Huron

Free communications 10: Skeletal Muscle 1

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Chair: Robyn Murphy

0845 129P Low dose formoterol treatment reverses sarcopenia and improves muscle function in fast- but not slow-twitch skeletal muscles of aged rats G.S. Lynch and J.G. Ryall, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia.
0900 130P β-adrenergic signalling in skeletal muscle regeneration after myotoxic injury F. Beitzel1, M.N. Sillence2 and G.S. Lynch1, 1Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia and 2School of Agriculture, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
0915 131P Streptomycin reduces stretch-induced membrane permeability in isolated muscles from mdx (dystrophic) mice N.P. Whitehead, M. Streamer and D.G. Allen, School of Medical Sciences, University of Sydney (F13), NSW 2006, Australia.
0930 132P Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofibre repair mechanism A.J. Kee, J.E. Joya, V. Nair-Shalliker, M.-A. Nguyen, M. Ghoddusi and E.C. Hardeman, Muscle Development Unit, Children’s Medical Research Institute, Westmead, NSW 2145, Australia.
0945 133P Contraction-mediated damage in mdx dystrophic mouse tibialis anterior muscles is not affected by the membrane sealant poloxamer D.R. Plant, J.G. Ryall and G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1000 134P Aberrant splicing of ryanodine receptor reduces Ca2+ release via an inter-domain interaction in myotonic dystrophy type 1 T. Kimura1,2, M. Nakamori2, J.D. Lueck3, P. Pouliquin1, R.T. Dirksen3, M.P. Takahashi2, S. Sakoda2 and A.F. Dulhunty1, 1Muscle Research, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia, 2Clinical Neuroscience (Neurology), Graduate School of Medicine, Osaka University, Suita, Osaka, Japan and 3Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
1015-1045 Morning Tea

Free communications 11: Skeletal muscle 2

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Chair: Gordon Lynch

1045 135P The effect of altering the rest period during interval training on adaptations to muscle metabolism, ion regulation and exercise performance J. Edge, D. Bishop and C. Goodman, School of Human Movement and Exercise Science, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia.
1100 136P Long lasting muscle fatigue: partial disruption of EC-coupling by the elevated cytosolic calcium during contractions E. Verburg, T.L. Dutka and G.D. Lamb, Department of Zoology, La Trobe University Bundoora Campus, Melbourne, VIC 3086, Australia.
1115 137P The role of reactive oxygen species on stretch-induced muscle damage in dystrophic mice D.G. Allen1 and E.Y. Yeung2, 1School of Medical Sciences, University of Sydney F13, NSW 2006, Australia and 2Department of Rehhabilitation Sciences, Hong Kong Polytechnic University, Hong Kong.
1130 138P Effects of raising the temperature from 25°C to 37°C on twitch responses in fast-twitch mechanically skinned muscle fibres of the rat C. van der Poel, J. Edwards and D.G. Stephenson, Department of Zoology, La Trobe University, VIC 3086, Australia.
1145 139P Exposure of mammalian skeletal muscle to sub-physiological temperatures reduces its ability to function at physiological temperatures J. Edwards, C. van der Poel and D.G. Stephenson, Department of Zoology, La Trobe University, VIC 3086, Australia.

Free communications 12: Systems physiology

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Chair: Rick Lang

1045 140P Novel nifedipine-insensitive high voltage activated calcium channels play a role in vascular tone of cerebral arteries M.F. Navarro-Gonzalez and C.E. Hill, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
1100 141P Accentuation during diabetes of differential connexin expression between the preglomerular and postglomerular renal vasculature J.H. Zhang and C.E. Hill, Division of Neuroscience, JCSMR, ANU, Acton, ACT 2602, Australia.
1115 142P High-amplitude oscillations in human skin blood flow are distinct from known cardiac or respiratory influences C.D. Haley, C.J. Gordon, N.A. S. Taylor and A.B. Jenkins, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia.
1130 143P Activation of at least three classes of ion channels by β-adrenoceptor activation in pregnant uterine smooth muscle H.C. Parkington, M.A. Tonta, S. Simon, S.A. Cohen, A. Satragno, R.J. Lang and H.A. Coleman, Department of Physiology, Monash University, Vic 3800, Australia.
1145 144P Expression of a constitutively active K+ channel prevents cell division in the mouse preimplantation embryo M.L. Day1, C.G. Bailey2, J.E. Rasko2, M.H. Johnson3 and D.I. Cook1, 1Physiology, School of Medical Sciences, University of Sydney, NSW 2006, Australia, 2Gene Therapy, Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, NSW 2042, Australia and 3Department of Anatomy, Downing St., University of Cambridge, CB2 3DY, UK.
1200-1245 Lunch - Joint meeting AuPS/ASB - Student Prizes - Chair: Peter Barry

Symposium 7: Function and Regulation of Ion Transport Membrane Proteins

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Chair: Ron Clarke

1245 145P The transition between gating states in inward rectifier K+ channels J. Gulbis, Structural Biology Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, VIC 3052, Australia.
1305 146P Channelrhodopsin 1,2, a new class of ion channels: functional description and cellular applications Georg Nagel1, Peter Hegemann2, Suneel Kateriya2 and Ernst Bamberg1, 1Max-Planck-Institut für Biophysik, Frankfurt, Germany and 2Institute of Biology, Humboldt University, Berlin, Germany.
1325 147P Membrane lipid composition and its effect on Na+,K+-ATPase molecular activity: insights from mammals, birds and ectotherms N. Turner1,2,4, P.L. Else1,2, B.J. Wu1,2 and A.J. Hulbert1,3, 1Metabolic Research Centre, 2Department of Biomedical Science and 3School of Biological Sciences, University of Wollongong, Wollongong NSW 2522, Australia (4Present address: Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia.
1355 148P Testing the membrane pacemaker model of metabolism Paul L. Else1, Nigel Turner1, Todd W. Mitchell1, Ben J. Wu1 and Anthony J. Hulbert2, 1Metabolic Research Centre, Department of Biomedical Science University of Wollongong, Wollongong, NSW 2522, Australia and 2Metabolic Research Centre, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia. (Introduced by R. Clarke)
1420 149P Regulation of the Na,K-ATPase Helge Rasmussen, Department of Cardiology, Royal North Shore Hospital, and Department of Medicine, University of Sydney, NSW, Australia.
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Symposium 8: Epithelial Transport of Ions and Metabolites

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Chair: Stefan Bröer, David Cook

1245 150P A systems biology approach to understanding the role of peptide transporters in biology H. Daniel, Meissner, B. Spanier, D. Weitz and I. Frey, Molecular Nutrition Unit, Technical University of Munich, Am forum 5, D-85350 Freising-Weihenstephan, Germany.
1315 151P Na+-H+ exchange regulatory factors NHERF-1 and NHERF-2: roles in albumin endocytosis in the proximal tubule P. Poronnik1, C. Ferguson2, R. Parton2, C.H. Yun3 and D.H. Hryciw1, 1School of Biomedical Science, The University of Queensland, Brisbane, QLD 4072, Australia, 2Institute of Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia and 3Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, USA.
1335 152P Sulphate ions in mammalian physiology: lessons from sulphate transporter knock-out mice P.A. Dawson1, B. Gardiner2, S. Lee1, M.C. Ku1, S.M. Grimmond2 and D. Markovich1, 1School of Biomedical Sciences, and 2Institute of Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
1355 153P Regulation of epithelial Na+ channels A. Dinudom, I.-H. Lee and D.I. Cook, School of Medical Sciences, University of Sydney, NSW 2006, Asutralia.
1420 154P Disorders of neutral amino acid resorption in epithelial cells S. Bröer, School of Biochemistry & Molecular Biology, Australian National University, Canberra, ACT 0200, Australia.
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1445 AuPS Annual General Meeting
1545 Close
1445 ASB General Meeting
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End of Conference

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